TBM Hunter
Search and score tankyrase-binding motifs
Enter UniProt code(s) below, one code per line:
Canonical TBMs: (R-x-x-x-x-G-(No proline)-x)
Extended TBMs: (R-x-x-x-D/E-G-x-x), with 5, 6, or 7 amino acids between R and G
Input one sequence of 8 amino acids to be scored:
Score any 8-residue peptide sequence regardless of the presence of R1/G6, using canonical score system.
Note: Scores are a prediction and do not replace experimental data.
Tips and Tricks:
Please cite the following articles in any publication that uses analysis or studies inspired by or benefiting from TBM Hunter:
Website creators: Samantha Shellman and Melody Shellman
Contact: Yiqun.Shellman@cuanschutz.edu
- Protocol for using this site: A Computational Method for detecting and evaluating Tankyrase-Binding Motifs. Protocols.io, 2023.
- A list of UniProt codes from a column in an Excel file can be copied and pasted into the entry box.
- Tool outputs can be downloaded by the download buttons or copied and pasted directly into an Excel file and delimited by commas.
- Larger scores suggest more favorable binding.
- TBMs should be in unstructured regions, see helpful links below for more info.
- When processing a large number of UniProt codes (500+), the tool may not return results. If encountering issues, consider running the tool with a reduced number of codes.
- Holistic TBM identification and validation: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6082341
- Canonical Score: https://pubmed.ncbi.nlm.nih.gov/22153077/
Please cite the following articles in any publication that uses analysis or studies inspired by or benefiting from TBM Hunter:
- Clements CM, Shellman SX, Shellman MH, Shellman YG. A Computational Method for detecting and evaluating Tankyrase-Binding Motifs. Protocols.io, 2023. dx.doi.org/10.17504/protocols.io.n2bvj32xplk5/v1. Sci. 2023; 24(23): 16964.
- Clements CM, Shellman SX, Shellman MH, Shellman YG. TBM Hunter: identify and score canonical, extended, and unconventional Tankyrase-binding motifs in any protein. Int. J. Mol. Sci. 2023; 24(23): 16964. https://doi.org/10.3390/ijms242316964
Website creators: Samantha Shellman and Melody Shellman
Contact: Yiqun.Shellman@cuanschutz.edu